Comparative analysis of sediment extracts from NOAA's bioeffects studies by the biomarker, P450 Reporter Gene System

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dc.acquisition-srcDownloaded from-Aquatic Sciences and Fisheries Abstractsen_US
dc.call-noen_US
dc.contract-noen_US
dc.contributor.authorAnderson JWen_US
dc.contributor.authorJones JMen_US
dc.contributor.authorHameedi Jen_US
dc.contributor.authorLong Een_US
dc.contributor.authorTukey RHen_US
dc.contributor.otheren_US
dc.date.accessioned2010-02-15T17:13:45Z
dc.date.available2010-02-15T17:13:45Z
dc.date.issued1999en_US
dc.degreeen_US
dc.description-en_US
dc.description-otheren_US
dc.description.abstractSediment samples collected from nine coastal and estuarine areas have been analyzed to determine response of a biomarker, P450 Reporter Gene System (RGS). This biomarker, using a transgenic cell line, detects the presence and potency of organic compounds that typically induce the CYP1A gene. Previous investigations have shown that sediments containing chemicals which produce a response of 60 or more mu g/g of benzo[a]pyrene equivalents (B[a]PEq) also exhibited a degraded community structure. RGS data from all study areas combined (527 samples) show that the mean response is 22.7 mu g/g B[a]Peq, and the mean upper 99% confidence interval is 32. We believe that sediments exhibiting B[a]Peq values of 32-60 are possibly contaminated to the extent that effects on benthic organisms may be observed, and those producing an RGS response of 60 and greater are likely to contain levels of chemicals that will produce chronic toxicity. The majority of the stations investigated produced responses below 32 mu g/g B[a]Peq. No samples from coastal southern California produced responses greater than 39. However, samples producing induction over 60 mu g/g B[a]Peq were: 50%, an Diego Bay; 16%, Delaware Bay; 8%, Sabine Lake; 4%, Northern Puget Sound; and 3%, Charleston Harbor. A strong statistical correlation was observed between the RGS responses and high molecular weight polycyclic aromatic hydrocarbon concentrations in the sediments from several of the study areas. Of the 2695 km super(2) encompassed in the surveys, only 0.42% of the area exhibited responses above 32 mu g/g B[a]Peq, which represented 11.4 km super(2). This assay is useful in identifying high levels of toxic and carcinogenic compounds in the sediments and predicting the potential impact of these chemicals on the biological communityen_US
dc.description.urihttp://gbic.tamug.edu/request.htmen_US
dc.historyen_US
dc.identifier.urihttp://hdl.handle.net/1969.3/22979
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dc.locationen_US
dc.longitudeen_US
dc.notesSource Marine Environmental Research [Mar. Environ. Res.]. Vol. 48, no. 4-5, pp. 407-425. 19990141-1136EnglishEnglishJournal ArticleMarineMB0000265en_US
dc.placeen_US
dc.publisheren_US
dc.relation.ispartofseries50485.00en_US
dc.relation.urien_US
dc.scaleen_US
dc.seriesen_US
dc.subjectanalysisen_US
dc.subjectANW,USA,South Carolina,Charleston Harboren_US
dc.subjectAromatic hydrocarbonsen_US
dc.subjectASW,USA,Florida,Biscayne Bayen_US
dc.subjectASW,USA,South Carolina,Winyah Bayen_US
dc.subjectASW,USA,Texas,Galveston Bayen_US
dc.subjectbiologicalen_US
dc.subjectBiomarkersen_US
dc.subjectchemicalsen_US
dc.subjectchronic toxicityen_US
dc.subjectcommunity structureen_US
dc.subjectEnvironmental impacten_US
dc.subjectHydrocarbonen_US
dc.subjectINE,USA,Californiaen_US
dc.subjectINE,USA,California,San Diego Bayen_US
dc.subjectMolecular weighten_US
dc.subjectorganic compoundsen_US
dc.subjectPollution monitoringen_US
dc.subjectPublic healthen_US
dc.subjectQ5 01502 Methods and instrumentsen_US
dc.subjectSedimenten_US
dc.subjectSedimentsen_US
dc.subjectToxicityen_US
dc.subjectUSAen_US
dc.titleComparative analysis of sediment extracts from NOAA's bioeffects studies by the biomarker, P450 Reporter Gene Systemen_US
dc.typeReporten_US
dc.universityen_US
dc.vol-issue()en_US

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