The objective of Volume 2: Risk Assessment and Fish Consumption Limits is to provide guidance on the development of risk-based meal consumption limits for 25 high-priority chemical contaminants (target analytes). The target analytes addressed in this guidance series were selected by EPA's Office of Water as particularly significant contaminants, based on their documented occurrence in fish and shellfish, their persistence in the environment, their potential for bioaccumulation, and their oral toxicity to humans. The criteria for their selection are discussed in Section 4 of Volume 1 of this series.