An updated review of environmental estrogen and androgen mimics and antagonists

dc.acquisition-srcILL completed for Dr. Parmer, TNRCC, working on contaminants subjecten_US
dc.call-noAcc# 8949en_US
dc.contract-noen_US
dc.contributor.authorSonnenschein, C.en_US
dc.contributor.authorSoto, A.M.en_US
dc.contributor.otherSteroid Biochemistry & Molecular Biologyen_US
dc.date.accessioned2010-02-15T17:35:49Z
dc.date.available2010-02-15T17:35:49Z
dc.date.issued1998en_US
dc.degreeen_US
dc.descriptionp. 143-150en_US
dc.description-otheren_US
dc.description.abstractSubstantial evidence has surfaced on the hormone-like effects of environmental chemicals such as pesticides and industrial chemicals in wildlife and humans. The endocrine and reproductive effects of these chemicals are believed to be due to their ability to: (1) mimic the effect of endogenous hormones, (2) antagonize the effect of endogenous hormones, (3) disrupt the synthesis and metabolism of endogenous hormones, and (4) disrupt the synthesis and metabolism of hormone receptors. The discovery of hormone-like activity of these chemicals occurred long after they were released into the environment. Subsequently, experiments conducted in lab animals demonstrated unambiguously the estrogenic activity of these pesticides. Estrogen mimics are just a class of endocrine disruptors. Recent studies identified antiandrogenic activity in environmental chemicals such as vinclozolin, a fungicide, and DDE, an insecticide. Moreover, a single chemical may produce neurotoxic, estrogenic and antiandrogenic effects. It has been hypothesized that endocrine disruptors may play a role in the decrease in the quantity and quality of human semen in the last 50 years, as well as in the increased incidence of testicular cancer and cryptorchidism in males and breast cancer in both females and males in the industrialized world.en_US
dc.description.urihttp://gbic.tamug.edu/request.htmen_US
dc.geo-codeUnited Statesen_US
dc.historyen_US
dc.identifier.urihttp://hdl.handle.net/1969.3/26024
dc.latitudeen_US
dc.locationGBIC Collectionen_US
dc.longitudeen_US
dc.notesen_US
dc.placeen_US
dc.publisheren_US
dc.relation.ispartofseries8949.00en_US
dc.relation.urien_US
dc.scaleen_US
dc.seriesen_US
dc.subjectDDTen_US
dc.subjectchemical pollutionen_US
dc.subjecthazardous materialsen_US
dc.subjectpesticidesen_US
dc.subjecthuman impacten_US
dc.titleAn updated review of environmental estrogen and androgen mimics and antagonistsen_US
dc.typeArticleen_US
dc.universityen_US
dc.vol-issue65(1)en_US

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